A placebo-controlled trial of valproate for agitation and aggression in Alzheimer's disease.

@article{Herrmann2007APT,
  title={A placebo-controlled trial of valproate for agitation and aggression in Alzheimer's disease.},
  author={Nathan Herrmann and Krista L. Lanct{\^o}t and Lana S Rothenburg and Goran M. Eryavec},
  journal={Dementia and geriatric cognitive disorders},
  year={2007},
  volume={23 2},
  pages={116-9}
}
BACKGROUND/AIMS To assess the efficacy and tolerability of valproate for the treatment of agitation and aggression in moderate-to-severe Alzheimer's disease (AD). METHODS This was a randomized, double-blind, placebo-controlled crossover trial of valproate in institutionalized AD patients. Patients were assessed with the Neuropsychiatric Inventory (NPI) and Cohen-Mansfield Agitation Inventory at baseline and after 6 weeks of treatment with valproate and placebo, with 2 weeks between phases to… CONTINUE READING

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