A placebo-controlled randomized trial of warfarin in idiopathic pulmonary fibrosis.

@article{Noth2012APR,
  title={A placebo-controlled randomized trial of warfarin in idiopathic pulmonary fibrosis.},
  author={Imre Noth and Kevin J. Anstrom and Sara B Calvert and Joao A de Andrade and Kevin R. Flaherty and Craig S. Glazer and Robert J Kaner and Mitchell A. Olman},
  journal={American journal of respiratory and critical care medicine},
  year={2012},
  volume={186 1},
  pages={88-95}
}
RATIONALE Animal and human studies support the importance of the coagulation cascade in pulmonary fibrosis. OBJECTIVES In a cohort of subjects with progressive idiopathic pulmonary fibrosis (IPF), we tested the hypothesis that treatment with warfarin at recognized therapeutic doses would reduce rates of mortality, hospitalization, and declines in FVC. METHODS This was a double-blind, randomized, placebo-controlled trial of warfarin targeting an international normalized ratio of 2.0 to 3.0… CONTINUE READING

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