A placebo-controlled comparison of lithium and triiodothyronine augmentation of tricyclic antidepressants in unipolar refractory depression.

@article{Joffe1993APC,
  title={A placebo-controlled comparison of lithium and triiodothyronine augmentation of tricyclic antidepressants in unipolar refractory depression.},
  author={Russell T. Joffe and Wolfgang Singer and Anthony J. Levitt and Charlotte J. Macdonald},
  journal={Archives of general psychiatry},
  year={1993},
  volume={50 5},
  pages={
          387-93
        }
}
OBJECTIVE To directly compare the efficacy of lithium carbonate and liothyronine sodium (triiodothyronine) in the augmentation of therapeutic response in antidepressant nonresponders. DESIGN A randomized, double-blind, placebo-controlled study of 2 weeks' duration. SETTING The Mood Disorders Program, Clarke Institute of Psychiatry and the University of Toronto, Ontario. PATIENTS Fifty outpatients, males and females, with unipolar, nonpsychotic major depression who had failed to respond to… CONTINUE READING

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