A placebo-controlled, double-blind, randomized trial of cyclosporine therapy in active chronic Crohn's disease.

@article{Brynskov1989APD,
  title={A placebo-controlled, double-blind, randomized trial of cyclosporine therapy in active chronic Crohn's disease.},
  author={J\orn Brynskov and Lisa M Freund and Sten N\orby Rasmussen and Karsten Lauritsen and Ove Schaffalitsky de Muckadell and Noel Williams and Allan S Macdonald and Robert Tanton and Francisco Molina and Marianne Campanini},
  journal={The New England journal of medicine},
  year={1989},
  volume={321 13},
  pages={845-50}
}
We randomly assigned 71 patients with active chronic Crohn's disease who were resistant to or intolerant of corticosteroids to treatment with oral cyclosporine (5 to 7.5 mg per kilogram of body weight per day) or placebo for three months. Disease activity was assessed on a clinical grading scale without knowledge of the treatment given. At the end of the treatment period, 22 of the 37 cyclosporine-treated patients (59 percent) had improvement, as compared with 11 of the 34 placebo-treated… CONTINUE READING

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