A pivoting algorithm for metabolic networks in the presence of thermodynamic constraints

  • R. Nigam, S. Liang
  • Published 2005 in
    2005 IEEE Computational Systems Bioinformatics…


A linear programming algorithm is presented to constructively compute thermodynamically feasible fluxes and change in chemical potentials of reactions for a metabolic network. It is based on physical laws of mass conservation and the second law of thermodynamics that all chemical reactions should satisfy. As a demonstration, the algorithm has been applied… (More)
DOI: 10.1109/CSB.2005.6


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