A pivotal role of matrix metalloproteinase‐3 activity in dopaminergic neuronal degeneration via microglial activation

@article{Kim2007APR,
  title={A pivotal role of matrix metalloproteinase‐3 activity in dopaminergic neuronal degeneration via microglial activation},
  author={Yoon-Seong Kim and Dong-Hee Choi and Michelle L. Block and Stefan Lorenzl and Lichuan Yang and Youn Jung Kim and Shuei Sugama and Byung Pil Cho and Onyou Hwang and Susan E. Browne and Soo Yul Kim and Jau-Shyong Hong and M. Flint Beal and Tong Hyub Joh},
  journal={The FASEB Journal},
  year={2007},
  volume={21},
  pages={179 - 187}
}
Recent studies have demonstrated that activated microglia play an important role in dopamine (DA) neuronal degeneration in Parkinson disease (PD) by generating NADPH‐oxidase (NADPHO)‐derived superoxide. However, the molecular mechanisms that underlie microglial activation in DA cell death are still disputed. We report here that matrix metalloproteinase‐3 (MMP‐3) was newly induced and activated in stressed DA cells, and the active form of MMP‐3 (actMMP‐3) was released into the medium. The… 

A novel intracellular role of matrix metalloproteinase‐3 during apoptosis of dopaminergic cells

ActMMP‐3 seems to have a novel intracellular role in apoptotic DArgic cells and this finding provides an insight into the pathogenesis of Parkinson’s disease.

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Matrix metalloproteinase‐3 in the central nervous system: a look on the bright side

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The studies suggest that MPP+ suppresses miR‐7116‐5p level in microglia and potentiates TNF‐α production and inflammatory responses to contribute to DA neuron damage.

Doxycycline is Neuroprotective Against Nigral Dopaminergic Degeneration by a Dual Mechanism Involving MMP-3

Doxycycline showed neuroprotective effect on DAergic system both in vitro and in vivo and this appeared to derive from anti-apoptotic and anti-inflammatory mechanisms involving downregulation of MMP-3.

Apoptosis Signal-Regulating Kinase 1 Mediates MPTP Toxicity and Regulates Glial Activation

It is found that MPTP administration to wild-type mice activates ASK1 in the midbrain, and inhibiting this kinase is a plausible therapeutic strategy for protecting dopamine neurons in PD.

Matrix Metalloproteinase-3 Causes Dopaminergic Neuronal Death through Nox1-Regenerated Oxidative Stress

Novel molecular mechanisms underlying oxidative stress-mediated dopaminergic neuronal death are established in which MMP3 activation is a key upstream event that leads to mitochondrial ROS, Nox1 induction and eventual dopamine neuronal death.

Microglial involvement in brain physiopathology: in vitro studies using rat primary cultures

The microglial M1/M2 phenotype in transgenic rats (McGill-R-Thy1-APP) which reproduce extensively the Alzheimer’s-like amyloid pathology is characterized and could represent a target for manipulation aimed at promoting neuroprotection in brain diseases.
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