A pivotal role for glutamate in the pathogenesis of schizophrenia, and its cognitive dysfunction.

@article{Hirsch1997APR,
  title={A pivotal role for glutamate in the pathogenesis of schizophrenia, and its cognitive dysfunction.},
  author={Steven Richard Hirsch and I. M. L. Das and Laurence J. Garey and Jacqueline de Belleroche},
  journal={Pharmacology, biochemistry, and behavior},
  year={1997},
  volume={56 4},
  pages={797-802}
}
There is mounting evidence of a glutamate dysfunction in schizophrenia, as suggested by the fact that schizophrenia and phencyclidine psychosis are similar and phencyclidine is known to block the N-methyl-D-aspartate (NMDA) subtypes of glutamate. Both occur mainly after puberty, suggesting they may share similar underlying developmental processes. Direct evidence is now accumulating from the study of messenger RNA that glutamate receptor deficiencies occur in schizophrenia and are regionally… CONTINUE READING

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