A pivotal role for PINK1 and autophagy in mitochondrial quality control: implications for Parkinson disease.

@article{Chu2010APR,
  title={A pivotal role for PINK1 and autophagy in mitochondrial quality control: implications for Parkinson disease.},
  author={Charleen T Chu},
  journal={Human molecular genetics},
  year={2010},
  volume={19 R1},
  pages={
          R28-37
        }
}
The PTEN-induced putative kinase 1 (PINK1) is a mitochondrially targeted serine-threonine kinase, which is linked to autosomal recessive familial parkinsonism. Current literature implicates PINK1 as a pivotal regulator of mitochondrial quality control, promoting maintenance of respiring mitochondrial networks through cristae stabilization, phosphorylation of chaperones and possibly regulation of mitochondrial transport or autophagy. Pulse-chase studies indicate that PINK1 is rapidly processed… CONTINUE READING
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