A pilot trial of tandem autologous peripheral blood progenitor cell transplantation following high-dose thiotepa and carboplatin in children with poor-risk central nervous system tumors.

@article{Ozkaynak2004APT,
  title={A pilot trial of tandem autologous peripheral blood progenitor cell transplantation following high-dose thiotepa and carboplatin in children with poor-risk central nervous system tumors.},
  author={Mehmet Fevzi Ozkaynak and C Salazar Sandoval and Oya Levendoglu-Tugal and Somasundaram Jayabose},
  journal={Pediatric hematology and oncology},
  year={2004},
  volume={21 7},
  pages={635-45}
}
This is a pilot study performed to determine the maximum tolerated number of courses of high-dose thiotepa and carboplatin with autologous peripheral blood progenitor cell (PBPC) transplantation in poor-risk pediatric central nervous system (CNS) tumor patients. Twelve patients were enrolled and a total of 24 PBPC transplants were performed. The median age was 7.7 years. All patients had CNS tumors: 4 relapsed CNS PNET, 2 high-risk PNET in first remission, 2 relapsed/progressive brainstem tumor… CONTINUE READING

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