A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis

@inproceedings{Yoo2017APS,
  title={A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis},
  author={Seungyeul Yoo and Wenhui Wang and Qin Wang and Maria Isabel Fiel and Eunjee Lee and Spiros P. Hiotis and Jun Zhu},
  booktitle={BMC medicine},
  year={2017}
}
BACKGROUND Chronic hepatitis B virus (HBV) infection leads to liver fibrosis, which is a major risk factor in hepatocellular carcinoma (HCC) and an independent risk factor of recurrence after HCC tumor resection. The HBV genome can be inserted into the human genome, and chronic inflammation may trigger somatic mutations. However, how HBV integration and other genomic changes contribute to the risk of tumor recurrence with regards to the different degree of liver fibrosis is not clearly… CONTINUE READING
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