A pilot study of the safety and effects of the matrix metalloproteinase inhibitor marimastat in gastric cancer.

@article{Tierney1999APS,
  title={A pilot study of the safety and effects of the matrix metalloproteinase inhibitor marimastat in gastric cancer.},
  author={Gillian M Tierney and Nick R Griffin and Robert C. Stuart and Hussien H Kasem and Kevin P. Lynch and J T Lury and P D Brown and Andrew W. Millar and Robert J. C. Steele and Simon. L. Parsons},
  journal={European journal of cancer},
  year={1999},
  volume={35 4},
  pages={563-8}
}
The aim of this study was to evaluate the safety and tolerability of 4 weeks administration of marimastat, and to seek evidence of biological activity as observed by changes in the endoscopic appearance of the gastric tumours. 35 patients with advanced, inoperable gastric or gastro-oesophageal tumours were recruited. The dose of marimastat was reduced from the starting dose of 50 mg twice daily (6 patients) to 25 mg once daily (29 patients). 31 completed the 28 day study period. Marimastat was… CONTINUE READING
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