A pilot study of the role of the claustrum in attention and seizures in rats

@article{Bayat2018APS,
  title={A pilot study of the role of the claustrum in attention and seizures in rats},
  author={Arezou Bayat and Sweta Joshi and Sahar Jahan and Phillip Connell and Komei Tsuchiya and David Chau and Tanvir U. Syed and Patrick A. Forcelli and Mohamad Z Koubeissi},
  journal={Epilepsy Research},
  year={2018},
  volume={140},
  pages={97-104}
}
OBJECTIVE The claustrum has been implicated in consciousness, and MRIs of patients with status epilepticus have shown increased claustral signal intensity. In an attempt to investigate the role of claustrum in cognition and seizures, we (1) assessed the effect of high-frequency stimulation (HFS) of the claustrum on performance in the operant chamber; (2) studied interclaustral and claustrohippocampal connectivity through cerebro-cerebral evoked potentials (CCEPs); and (3) investigated the role… 
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References

SHOWING 1-10 OF 51 REFERENCES
Further evidence for a role of the anterior claustrum in epileptogenesis
TLDR
Support is added to the notion that the CLA contributes to the development of generalized limbic seizures by finding an asymmetrical transfer of kindling to the CLA from the amygdala wherein amygdaloid kindling facilitated subsequent kindling of the CLA but kindled of the anterior CLA failed to facilitate kindlingof the amygdala.
The effect of claustrum lesions on human consciousness and recovery of function
Crick and Koch proposed that the claustrum plays a crucial role in consciousness. Their proposal was based on the structure and connectivity of the claustrum that suggested it had a role in
Susceptibility to Kindling and Neuronal Connections of the Anterior Claustrum
TLDR
The anatomical connections of the anterior claustrums are consistent with its very high susceptibility to kindling and support the view that the claustrum is part of a forebrain network of structures participating in the generalization of seizures.
Kindling of claustrum and insular cortex: comparison to perirhinal cortex in the rat
TLDR
It appears that the perirhinal cortex is not unique in its property of rapid epileptogenesis, and the posterior claustrum exhibited the fastest kindling and most vigorous patterns of clonus, suggesting that it may be even more intimately associated with the motor substrates responsible for limbic seizure generalization than is the periral cortex.
Interhemispheric resting-state functional connectivity of the claustrum in the awake and anesthetized states
TLDR
RS-fMRI data indicate that the claustrum has functional connections with mPFC and MD-thalamus that are significantly lessened by anesthesia.
ALTERATIONS OF BEHAVIOR FOLLOWING STIMULATION OF THE CLAUSTRUM OF THE CAT.
  • A. Gabor, T. Peele
  • Chemistry, Medicine
    Electroencephalography and clinical neurophysiology
  • 1964
TLDR
The claustrum, internal, external and extreme capsules, putamen and ectosylvian cortex of 27 awake, unrestrained cats were stimulated and changes in behavior were observed.
Rat Claustrum Coordinates But Does Not Integrate Somatosensory and Motor Cortical Information
TLDR
Although the rodent claustrum is probably involved in the interhemispheric coordination of the MI and SI whisker representations, it does not receive inputs from both of these cortical regions, and should not be universally regarded as an integrator of somesthetic and motor information.
Electrical stimulation of a small brain area reversibly disrupts consciousness
TLDR
The findings suggest that the left claustrum/anterior insula is an important part of a network that subserves consciousness and that disruption of consciousness is related to increased EEG signal synchrony within frontal-parietal networks.
Brain mechanisms of altered conscious states during epileptic seizures
TLDR
Novel insights into the brain mechanisms that underlie alterations of consciousness during epileptic seizures are reviewed and the implications for clinical practice in terms of diagnosis and management are reviewed.
New-Onset Refractory Status Epilepticus with Claustrum Damage: Definition of the Clinical and Neuroimaging Features
TLDR
Febrile illness-related SE associated with bilateral claustrum hyperintensity on MRI represents a condition with defined clinical features and a presumed but unidentified autoimmune etiology.
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