A pilot study of the effects of flumazenil on symptoms persisting after benzodiazepine withdrawal

@article{Lader1992APS,
  title={A pilot study of the effects of flumazenil on symptoms persisting after benzodiazepine withdrawal},
  author={M. Lader and S. Morton},
  journal={Journal of Psychopharmacology},
  year={1992},
  volume={6},
  pages={357 - 363}
}
The potential of the benzodiazepine antagonist flumazenil (Ro 15-1788) to lessen persisting benzodiazepine withdrawal symptoms was demonstrated in 11 patients who had been drug free for between 1 month and 5 years. Doses ranging from 0.2 to 2.0 mg divided into three intravenous injections over a few hours relieved long-standing symptoms to varying extents. These included clouded thinking, tiredness, muscular symptoms such as neck tension, cramps and shaking and the characteristic perceptual… Expand
26 Citations

Paper Mentions

Effects of flumazenil in the treatment of benzodiazepine withdrawal – a double-blind pilot study
  • 33
  • Highly Influenced
Withdrawing Benzodiazepines in Patients With Anxiety Disorders
  • 30
Flumazenil-precipitated withdrawal in healthy volunteers following repeated diazepam exposure
  • 17
Benzodiazepine dependence and its treatment with low dose flumazenil
  • 65
Pharmacological uses of flumazenil in benzodiazepine use disorders: a systematic review of limited data
  • 1
Anxiolytic drugs: dependence, addiction and abuse
  • M. Lader
  • Psychology, Medicine
  • European Neuropsychopharmacology
  • 1994
  • 59
...
1
2
3
...

References

SHOWING 1-10 OF 40 REFERENCES
Withdrawal reaction after long-term therapeutic use of benzodiazepines.
  • 285
Withdrawal from long-term benzodiazepine treatment.
  • 307
  • PDF
Long-term therapeutic use of benzodiazepines. I. Effects of abrupt discontinuation.
  • 260
A Clinical Scale to Assess Benzodiazepine Withdrawal
  • 80
Flumazenil: US clinical pharmacology studies.
  • 33
Long-term therapeutic use of benzodiazepines. II. Effects of gradual taper.
  • 157
...
1
2
3
4
...