A pilot study of penicillin prophylaxis for neuropsychiatric exacerbations triggered by streptococcal infections.

@article{Garvey1999APS,
  title={A pilot study of penicillin prophylaxis for neuropsychiatric exacerbations triggered by streptococcal infections.},
  author={Marjorie A Garvey and S J Perlmutter and Albert J. Allen and Stephan Hamburger and Lorraine C Lougee and Henrietta L. Leonard and M E Witowski and Billinda K Dubbert and Susan E. Swedo},
  journal={Biological psychiatry},
  year={1999},
  volume={45 12},
  pages={1564-71}
}
BACKGROUND Some children with obsessive-compulsive disorder (OCD) and tic disorders appear to have symptom exacerbations triggered by group A beta-hemolytic streptococcal infections in a manner that is similar to rheumatic fever and its neurologic variant, Sydenham's chorea. Because penicillin prophylaxis has proven to be effective in preventing recurrences of rheumatic fever, it was postulated that it might also prevent streptococcal-triggered neuropsychiatric symptom exacerbations in children… CONTINUE READING
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