A pilot study of oxaliplatin, fluorouracil and folinic acid (FOLFOX-6) as first-line chemotherapy in advanced or recurrent gastric cancer.

@article{Luo2008APS,
  title={A pilot study of oxaliplatin, fluorouracil and folinic acid (FOLFOX-6) as first-line chemotherapy in advanced or recurrent gastric cancer.},
  author={Hui-yan Luo and Ruihua Xu and Li Zhang and Yuan-hua Li and Yan-xia Shi and Tongyu Lin and Bing Han and Feng Wang and Miao-Zhen Qiu and You-jian He and Zhong-zhen Guan},
  journal={Chemotherapy},
  year={2008},
  volume={54 3},
  pages={228-35}
}
BACKGROUND To evaluate the efficacy and toxicity of an oxaliplatin, fluorouracil (5-FU), and folinic acid (FOLFOX-6) combination therapy in patients with advanced or recurrent gastric cancer. METHODS Patients with previously untreated advanced or recurrent gastric cancer received oxaliplatin 100 mg/m(2) and leucovorin 400 mg/m(2) (2-hour intravenous infusion) followed by a 5-FU bolus of 400 mg/m(2) (10-min infusion) and then 5-FU 2,600-3,000 mg/m(2) (46-hour continuous infusion). The… CONTINUE READING
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