A pilot study of oral bioavailability of dioxins and furans from contaminated soils: Impact of differential hepatic enzyme activity and species differences.

@article{Budinsky2008APS,
  title={A pilot study of oral bioavailability of dioxins and furans from contaminated soils: Impact of differential hepatic enzyme activity and species differences.},
  author={Robert A. Budinsky and Justin Craig Rowlands and Stan W. Casteel and Gunnar Fent and Colleen A Cushing and John L. Newsted and John Paul Giesy and Michael V. Ruby and Less L. Aylward},
  journal={Chemosphere},
  year={2008},
  volume={70 10},
  pages={1774-86}
}
An in vivo pilot study of the oral bioavailability of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in two soils with distinct congener profiles (one dominated by PCDDs, the other by PCDFs) was conducted in rats and juvenile swine. The pilot study revealed potential confounding of relative bioavailability estimates compared to bioavailability in spiked corn oil gavage for tetrachlorodibenzofuran (TCDF) in the rat study due to differential EROD induction… CONTINUE READING
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