A pilot study of cell-mediated gene therapy for spinal cord injury in mini pigs.

@article{Islamov2017APS,
  title={A pilot study of cell-mediated gene therapy for spinal cord injury in mini pigs.},
  author={Rustem Robertovich Islamov and Mikhail Evgenyevich Sokolov and Farid Vagizovich Bashirov and Filip Olegovich Fadeev and Maxim Michaylovich Shmarov and Boris Savelyevich Naroditskiy and Tatyana Vyacheslavovna Povysheva and Gulnara Ferdinantovna Shaymardanova and Radik Albertovich Yakupov and Yuri Aleksandrovich Chelyshev and Igor Aleksandrovich Lavrov},
  journal={Neuroscience letters},
  year={2017},
  volume={644},
  pages={
          67-75
        }
}
Currently, in clinical practice there is no efficient way to overcome the sequences of neurodegeneration after spinal cord traumatic injury. Using a new experimental model of spinal cord contusion injury on miniature pigs, we proposed to deliver therapeutic genes encoding vascular endothelial growth factor (VEGF), glial cell line-derived neurotrophic factor (GDNF) and neural cell adhesion molecule (NCAM) to the damaged area, using umbilical cord blood mononuclear cells (UCBC). In this study… CONTINUE READING