A pilot study of alpha-interferon and plicamycin for accelerated phase of chronic myeloid leukemia.

@article{Dutcher1997APS,
  title={A pilot study of alpha-interferon and plicamycin for accelerated phase of chronic myeloid leukemia.},
  author={Janice P Dutcher and Domenick P Coletti and Elisabeth Paietta and Peter H. Wiernik},
  journal={Leukemia research},
  year={1997},
  volume={21 5},
  pages={375-80}
}
Thirteen patients with accelerated phase of chronic myeloid leukemia (CML-AC) were treated with intravenous plicamycin and subcutaneous alpha-interferon. Two patients stabilized, three patients had partial hematologic responses and one patient had a hematologic complete response with a major cytogenetic response. Two patients, progressing on hydroxyurea, did not respond, but demonstrated re-sensitization to hydroxyurea after completion of induction therapy and had prolonged return to chronic… CONTINUE READING
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