A pilot study of a thiazolidinedione, troglitazone, in nonalcoholic steatohepatitis

@article{Caldwell2001APS,
  title={A pilot study of a thiazolidinedione, troglitazone, in nonalcoholic steatohepatitis},
  author={Stephen Hugh Caldwell and Elizabeth Erickson Hespenheide and Jan A. Redick and Julia C. Iezzoni and Emily H Battle and Bonnie L Sheppard},
  journal={American Journal of Gastroenterology},
  year={2001},
  volume={96},
  pages={519-525}
}
OBJECTIVES:Troglitazone is a thiazolidinedione and peroxisome proliferator–activated receptor gamma (PPARγ) ligand used to treat diabetes mellitus type II. Because hyperinsulinemia may be a factor in nonalcoholic steatohepatitis (NASH), we postulated that troglitazone could have beneficial effects in this disorder. Our study was initiated before reports of idiosyncratic hepatitis induced by this agent and was completed before its recent withdrawal from the market.METHODS:We studied 10 female… CONTINUE READING