A pilot study of a new therapeutic approach in the treatment of locally advanced stages of rectal cancer: neoadjuvant radiation, chemotherapy and regional hyperthermia.

@article{Riess1995APS,
  title={A pilot study of a new therapeutic approach in the treatment of locally advanced stages of rectal cancer: neoadjuvant radiation, chemotherapy and regional hyperthermia.},
  author={Hanno B Riess and J{\"u}rgen L{\"o}ffel and Peter Wust and B. Shankar Rau and M Gremmler and Andreia Speidel and Peter M. Schlag},
  journal={European journal of cancer},
  year={1995},
  volume={31A 7-8},
  pages={1356-60}
}
The synergistic effects of hyperthermia (temperatures > or = 41 degrees C) when combined with radiotherapy or cytotoxic drugs, as well as a modulation of tumour-related immunological phenomena have been demonstrated preclinically. Local or regional hyperthermia in combination with radiation or chemotherapy has been studied in patients during recent years, and has convincingly demonstrated that hyperthermia is feasible and tolerated by patients. Furthermore, there is strong evidence that… CONTINUE READING
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