A pilot open label prospective study of memantine monotherapy in adults with ADHD

  title={A pilot open label prospective study of memantine monotherapy in adults with ADHD},
  author={Craig B. H. Surman and Paul G. Hammerness and Carter R. Petty and Thomas J. Spencer and Robert L. Doyle and Siena Napolean and Nicole Chu and Dayna M Yorks and Joseph Biederman},
  journal={The World Journal of Biological Psychiatry},
  pages={291 - 298}
Abstract Objectives. Available pharmacotherapies treat some adults with ADHD inadequately. A small literature suggests that glutamate modulation could have effects on ADHD. Methods. Memantine, an N‐methyl‐d‐aspartate (NMDA) receptor antagonist, was titrated to a maximum dose of 10 mg BID in 34 adult subjects aged 18–55 who met DSM-IV criteria for ADHD or ADHD NOS on structured interview. Twenty-eight subjects completed 12 weeks exposure. The Adult ADHD Investigator Symptom Report (AISRS… 

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  • J. FayyadR. de Graaf R. Jin
  • Medicine, Psychology
    The British journal of psychiatry : the journal of mental science
  • 2007
Estimates of ADHD prevalence and correlates in the World Health Organization World Mental Health Survey Initiative should be considered more seriously in future epidemiological and clinical studies than is currently the case.