A pilot open label prospective study of memantine monotherapy in adults with ADHD

@article{Surman2013APO,
  title={A pilot open label prospective study of memantine monotherapy in adults with ADHD},
  author={Craig B. H. Surman and Paul G. Hammerness and Carter R. Petty and Thomas J. Spencer and Robert L. Doyle and Siena Napolean and Nicole Chu and Dayna M Yorks and Joseph Biederman},
  journal={The World Journal of Biological Psychiatry},
  year={2013},
  volume={14},
  pages={291 - 298}
}
Abstract Objectives. Available pharmacotherapies treat some adults with ADHD inadequately. A small literature suggests that glutamate modulation could have effects on ADHD. Methods. Memantine, an N‐methyl‐d‐aspartate (NMDA) receptor antagonist, was titrated to a maximum dose of 10 mg BID in 34 adult subjects aged 18–55 who met DSM-IV criteria for ADHD or ADHD NOS on structured interview. Twenty-eight subjects completed 12 weeks exposure. The Adult ADHD Investigator Symptom Report (AISRS… 

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References

SHOWING 1-10 OF 55 REFERENCES

Atomoxetine in adults with ADHD: two randomized, placebo-controlled studies

A pilot evaluation of the safety, tolerability, pharmacokinetics, and effectiveness of memantine in pediatric patients with attention-deficit/hyperactivity disorder combined type.

TLDR
This pilot study suggests that a memantine dose of 20 mg/day may be a safe and possibly effective treatment for pediatric ADHD and pharmacokinetic analyses suggest response to memantine may be dose-dependent beyond an initial threshold concentration.

Effects of stimulant medication on neuropsychological functioning in young adults with attention-deficit/hyperactivity disorder.

TLDR
This study showed that subjects with ADHD who took stimulant medication had higher neuropsychological measures of attention compared with subjects with attention-deficit/hyperactivity disorder who did not take stimulants, but differences were not found for other measures of executive function.

Neuropsychological function in adults with attention-deficit hyperactivity disorder

Neuropsychological Studies of Late Onset and Subthreshold Diagnoses of Adult Attention-Deficit/Hyperactivity Disorder

Memantine: a pharmacoeconomic review of its use in moderate-to-severe Alzheimer's disease.

TLDR
Available pharmacoeconomic data from Europe and the US, despite some inherent limitations, support the use of memantine as a cost-effective treatment in this patient population, although definitive conclusions are not feasible because of limited data.

Discordance Between Psychometric Testing and Questionnaire-Based Definitions of Executive Function Deficits in Individuals With ADHD

TLDR
Results indicate that behavioral questionnaires cannot be used interchangeably with neuropsychological testing for the assessment of EFDs in adults with ADHD.

Attention-deficit/hyperactivity disorder (adhd) as a noradrenergic disorder

Attention-deficit/hyperactivity disorder in adults: an overview

Cross-national prevalence and correlates of adult attention-deficit hyperactivity disorder.

  • J. FayyadR. de Graaf R. Jin
  • Medicine, Psychology
    The British journal of psychiatry : the journal of mental science
  • 2007
TLDR
Estimates of ADHD prevalence and correlates in the World Health Organization World Mental Health Survey Initiative should be considered more seriously in future epidemiological and clinical studies than is currently the case.
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