A pilot effectiveness study: placebo-controlled trial of adjunctive L-triiodothyronine (T3) used to accelerate and potentiate the antidepressant response.

@article{Posternak2008APE,
  title={A pilot effectiveness study: placebo-controlled trial of adjunctive L-triiodothyronine (T3) used to accelerate and potentiate the antidepressant response.},
  author={Michael A. Posternak and Scott Novak and Robert Stern and James V. Hennessey and Russell T. Joffe and A. Prange and Mark Zimmerman},
  journal={The international journal of neuropsychopharmacology},
  year={2008},
  volume={11 1},
  pages={
          15-25
        }
}
The aim was to evaluate whether adjunctive T3 can help accelerate the antidepressant response and improve overall outcomes when used under naturalistic conditions. Fifty consecutive psychiatric outpatients diagnosed with major depressive disorder who were initiated on antidepressant therapy were randomized to receive adjunctive T3 or placebo in a double-blind manner over the course of 6 wk. There were no restrictions placed on the selection of antidepressant agent, dosing, ancillary medications… CONTINUE READING

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