A pilot characterization of human lung NSCLC by protein pathway activation mapping.

@article{Zupa2012APC,
  title={A pilot characterization of human lung NSCLC by protein pathway activation mapping.},
  author={Angela Zupa and Giuseppina Improta and Alessandra Silvestri and Elisa Pin and Jianghong Deng and Michele Aieta and Pellegrino Musto and Donato Nitti and Enzo Mammano and Lance A. Liotta and Claudio Belluco and Julia D. Wulfkuhle and Emanual F. Petricoin},
  journal={Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
  year={2012},
  volume={7 12},
  pages={
          1755-1766
        }
}
BACKGROUND An understanding of the activated protein signaling architecture in non-small-cell lung cancer (NSCLC) is of critical importance to the development of new therapeutic approaches and identification of predictive and prognostic biomarkers for patient stratification. METHODS We used reverse-phase protein microarrays to map the activated protein signaling networks of 47 NSCLC tumors, 28 of which were node negative, which were subjected to tumor cellular enrichment using laser capture… CONTINUE READING
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