A pilot, double-blind, controlled 1-year trial of prednisolone treatment in primary biliary cirrhosis: hepatic improvement but greater bone loss.

@article{Mitchison1989APD,
  title={A pilot, double-blind, controlled 1-year trial of prednisolone treatment in primary biliary cirrhosis: hepatic improvement but greater bone loss.},
  author={H C Mitchison and Margaret Fiona Bassendine and Archie J. Malcolm and Alan M. Watson and Christopher Oswold Record and Oliver F. W. James},
  journal={Hepatology},
  year={1989},
  volume={10 4},
  pages={420-9}
}
A randomized, double-blind, 1-year pilot study of prednisolone treatment for primary biliary cirrhosis was undertaken. Nineteen patients received 30 mg prednisolone per day initially, with a maintenance dose of 10 mg per day. Seventeen patients received placebo. The groups were matched for age, menopausal status, hepatic histological stage and bilirubin. Treatment was well tolerated without dropouts. Two patients receiving prednisolone developed diabetes, one a duodenal ulcer and one depression… CONTINUE READING

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