A pig-to-mouse coronary artery transplantation model for investigating the pathogenicity of anti-pig antibody.

@article{Lin2015APC,
  title={A pig-to-mouse coronary artery transplantation model for investigating the pathogenicity of anti-pig antibody.},
  author={Yi Lin and Naoto Miyagi and Guerard W Byrne and Zeji Du and Heide Kogelberg and Mozammel Haque Gazi and Henry Dale Tazelaar and Chunsheng Wang and Christopher G A McGregor},
  journal={Xenotransplantation},
  year={2015},
  volume={22 6},
  pages={458-67}
}
BACKGROUND Rejection of Gal-free (GTKO) donor pig cardiac xenografts is strongly associated with vascular non-Gal antibody binding, endothelial cell (EC) injury, and activation and microvascular thrombosis. We adopted a pig-to-SCID/beige small animal transplant model to compare the pathogenicity of baboon and human anti-pig antibody. METHODS Wild-type (GT… CONTINUE READING