A picornavirus protein interacts with Ran-GTPase and disrupts nucleocytoplasmic transport.

@article{Porter2006APP,
  title={A picornavirus protein interacts with Ran-GTPase and disrupts nucleocytoplasmic transport.},
  author={Frederick W. Porter and Yury Alexandrovich Bochkov and Alison J. Albee and Christiane Wiese and Ann C Palmenberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 33},
  pages={
          12417-22
        }
}
Active nucleocytoplasmic transport of protein and RNA in eukaryotes depends on the Ran-GTPase system to regulate cargo-receptor interactions. Several viruses, including the RNA picornaviruses, encode factors that alter nuclear transport with the aim of suppressing synthesis of antiviral factors and promoting viral replication. Picornaviruses in the cardiovirus genus express a unique 67-aa Leader protein (L), known to alter the subcellular distribution of IFN regulatory proteins targeted to the… CONTINUE READING
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