A picorna-like virus suppresses the N-end rule pathway to inhibit apoptosis

@inproceedings{Wang2017APV,
  title={A picorna-like virus suppresses the N-end rule pathway to inhibit apoptosis},
  author={Zhaowei Wang and Xiaoling Xia and Xueli Yang and Xueyi Zhang and Yongxiang Liu and Di Wu and Yuan Fang and Yujie Liu and Jiuyue Xu and Yang Qiu and Xi Zhou},
  booktitle={eLife},
  year={2017}
}
The N-end rule pathway is an evolutionarily conserved proteolytic system that degrades proteins containing N-terminal degradation signals called N-degrons, and has emerged as a key regulator of various processes. Viruses manipulate diverse host pathways to facilitate viral replication and evade antiviral defenses. However, it remains unclear if viral infection has any impact on the N-end rule pathway. Here, using a picorna-like virus as a model, we found that viral infection promoted the… CONTINUE READING
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