A piRNA-like small RNA interacts with and modulates p-ERM proteins in human somatic cells

@inproceedings{Mei2015APS,
  title={A piRNA-like small RNA interacts with and modulates p-ERM proteins in human somatic cells},
  author={Yuping Mei and Yuyan Wang and Priti Kumari and Amol Carl Shetty and David J Clark and Tyler Gable and Alexander D. MacKerell and Mark Zhi-Qing Ma and David J. Weber and Austin J. Yang and Martin J. Edelman and Li Mao},
  booktitle={Nature communications},
  year={2015}
}
PIWI-interacting RNAs (piRNAs) are thought to silence transposon and gene expression during development. However, the roles of piRNAs in somatic tissues are largely unknown. Here we report the identification of 555 piRNAs in human lung bronchial epithelial (HBE) and non-small cell lung cancer (NSCLC) cell lines, including 295 that do not exist in databases termed as piRNA-like sncRNAs or piRNA-Ls. Distinctive piRNA/piRNA-L expression patterns are observed between HBE and NSCLC cells. piRNA-like… CONTINUE READING
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