A physiome interoperability roadmap for personalized drug development.

@article{Thomas2016API,
  title={A physiome interoperability roadmap for personalized drug development.},
  author={Simon Thomas and Katherine Wolstencroft and Bernard de Bono and Peter J. Hunter},
  journal={Interface focus},
  year={2016},
  volume={6 2},
  pages={20150094}
}
The goal of developing therapies and dosage regimes for characterized subgroups of the general population can be facilitated by the use of simulation models able to incorporate information about inter-individual variability in drug disposition (pharmacokinetics), toxicity and response effect (pharmacodynamics). Such observed variability can have multiple… CONTINUE READING