A physiologically-based flow network model for hepatic drug elimination II: variable lattice lobule models

@inproceedings{Rezania2013APF,
  title={A physiologically-based flow network model for hepatic drug elimination II: variable lattice lobule models},
  author={Vahid Rezania and Rebeccah E. Marsh and Dennis Coombe and Jack Adam Tuszynski},
  booktitle={Theoretical Biology and Medical Modelling},
  year={2013}
}
We extend a physiologically-based lattice model for the transport and metabolism of drugs in the liver lobule (liver functional unit) to consider structural and spatial variability. We compare predicted drug concentration levels observed exiting the lobule with their detailed distribution inside the lobule, and indicate the role that structural variation has on these results. Liver zonation and its role on drug metabolism represent another aspect of structural inhomogeneity that we consider… CONTINUE READING
BETA

Citations

Publications citing this paper.

References

Publications referenced by this paper.
SHOWING 1-10 OF 34 REFERENCES

An analysis of hydrodispersive transfer in aquifers

  • JP Sauty
  • Water Resour Res
  • 1980
Highly Influential
10 Excerpts

Validation and application of iterative coupling to poroelastic problems in bone fluid flow

  • GC Goulet, DML Cooper, D Coombe, RF Zernicke
  • Bulletin Applied Mechanics
  • 2009
1 Excerpt

Similar Papers

Loading similar papers…