A physiological role for gene loops in yeast.

  title={A physiological role for gene loops in yeast.},
  author={Jean-Philippe Lain{\'e} and Badri Nath Singh and Shankarling Krishnamurthy and Michael Hampsey},
  journal={Genes & development},
  volume={23 22},
DNA loops that juxtapose the promoter and terminator regions of RNA polymerase II-transcribed genes have been identified in yeast and mammalian cells. Loop formation is transcription-dependent and requires components of the pre-mRNA 3'-end processing machinery. Here we report that looping at the yeast GAL10 gene persists following a cycle of transcriptional activation and repression. Moreover, GAL10 and a GAL1p-SEN1 reporter undergo rapid reactivation kinetics following a cycle of activation… CONTINUE READING
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