A physiological role for androgen actions in the absence of androgen receptor DNA binding activity

@article{Pang2012APR,
  title={A physiological role for androgen actions in the absence of androgen receptor DNA binding activity},
  author={Tammy P S Pang and Michele V. Clarke and Ali Ghasem-Zadeh and Nicole K L Lee and Helen E. Maclean},
  journal={Molecular and Cellular Endocrinology},
  year={2012},
  volume={348},
  pages={189-197}
}
We tested the hypothesis that androgens have physiological actions via non-DNA binding-dependent androgen receptor (AR) signaling pathways in males, using our genetically modified mice that express a mutant AR with deletion of the 2nd zinc finger of the DNA binding domain (AR(ΔZF2)) that cannot bind DNA. In cultured genital skin fibroblasts, the mutant AR(ΔZF2) has normal ligand binding ability, phosphorylates ERK-1/2 in response to 1 min DHT treatment (blocked by the AR antagonist bicalutamide… CONTINUE READING

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