A physiological role for adrenomedullin in rats; a potent hypotensive peptide in the hypothalamo-neurohypophysial system.

@article{Ueta2000APR,
  title={A physiological role for adrenomedullin in rats; a potent hypotensive peptide in the hypothalamo-neurohypophysial system.},
  author={Yoichi Ueta and Ryota Serino and Izumi Shibuya and Kazuo Kitamura and Kenji Kangawa and John A. Russell and Hiroshi Yamashita},
  journal={Experimental physiology},
  year={2000},
  volume={85 Spec No},
  pages={163S-169S}
}
Adrenomedullin, a potent hypotensive peptide, was originally isolated from human phaeochromocytoma. Adrenomedullin immunoreactivity and gene expression are found not only in peripheral organs but also in the central nervous system. Adrenomedullin labelled cells were localised in the hypothalamus, including in the paraventricular and supraoptic nuclei, in rats. Abundant adrenomedullin-immunoreactive fibres and varicosities were found in the hypothalamo-neurohypophysial tract and the internal… CONTINUE READING

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Adrenomedullin influences magnocellular and parvocellular neurons of paraventricular nucleus via separate mechanisms.

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