A physiological mechanism to regulate D-aspartic acid and NMDA levels in mammals revealed by D-aspartate oxidase deficient mice.

@article{Errico2006APM,
  title={A physiological mechanism to regulate D-aspartic acid and NMDA levels in mammals revealed by D-aspartate oxidase deficient mice.},
  author={Francesco Errico and Maria Teresa Pirro and Andrea Affuso and Patrizia Spinelli and Mario De Felice and Antimo D'Aniello and Roberto Di Lauro},
  journal={Gene},
  year={2006},
  volume={374},
  pages={50-7}
}
Free D-aspartic acid and NMDA are present in the mammalian central nervous system and endocrine glands at significant concentrations, but their physiological role is still matter of debate. The only enzyme known to metabolize in vitro selectively these D-amino acids is D-aspartate oxidase (DDO). To clarify the role in vivo of the enzyme, we generated mice with targeted deletion of Ddo gene by homologous recombination. Mutated animals showed increased amounts of both D-aspartic acid and NMDA in… CONTINUE READING

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