A physiological connection between tmRNA and peptidyl-tRNA hydrolase functions in Escherichia coli.

@article{Singh2004APC,
  title={A physiological connection between tmRNA and peptidyl-tRNA hydrolase functions in Escherichia coli.},
  author={Nongmaithem Sadananda Singh and Umesh Varshney},
  journal={Nucleic acids research},
  year={2004},
  volume={32 20},
  pages={6028-37}
}
The bacterial ssrA gene codes for a dual function RNA, tmRNA, which possesses tRNA-like and mRNA-like regions. The tmRNA appends an oligopeptide tag to the polypeptide on the P-site tRNA by a trans-translation process that rescues ribosomes stalled on the mRNAs and targets the aberrant protein for degradation. In cells, processing of the stalled ribosomes is also pioneered by drop-off of peptidyl-tRNAs. The ester bond linking the peptide to tRNA is hydrolyzed by peptidyl-tRNA hydrolase (Pth… CONTINUE READING

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