A physical map of the human Y chromosome

  title={A physical map of the human Y chromosome},
  author={Charles A. Tilford and Tomoko Kuroda-Kawaguchi and Helen Skaletsky and Steve Rozen and Laura G. Brown and Michael I. Rosenberg and John D. McPherson and Kristine Wylie and Mandeep Sekhon and Tamara Kucaba and Robert H. Waterston and David C. Page},
The non-recombining region of the human Y chromosome (NRY), which comprises 95% of the chromosome, does not undergo sexual recombination and is present only in males. An understanding of its biological functions has begun to emerge from DNA studies of individuals with partial Y chromosomes, coupled with molecular characterization of genes implicated in gonadal sex reversal, Turner syndrome, graft rejection and spermatogenic failure. But mapping strategies applied successfully elsewhere in the… CONTINUE READING

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