A physical complex of the Fanconi anemia proteins FANCG/XRCC9 and FANCA.

@article{Waisfisz1999APC,
  title={A physical complex of the Fanconi anemia proteins FANCG/XRCC9 and FANCA.},
  author={Quinten Waisfisz and Johan P. de Winter and Frank A.E. Kruyt and Jan de Groot and Laura van der Weel and L M Dijkmans and Yu Zhi and Fr{\'e} Arwert and Rik J. Scheper and Hagop Youssoufian and Maureen Elizabeth Hoatlin and Hans Joenje},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 18},
  pages={10320-5}
}
Fanconi anemia (FA) is a recessively inherited disease characterized at the cellular level by spontaneous chromosomal instability and specific hypersensitivity to cross-linking agents. FA is genetically heterogeneous, comprising at least eight complementation groups (A-H). We report that the protein encoded by the gene mutated in complementation group G (FANCG) localizes to the cytoplasm and nucleus of the cell and assembles in a molecular complex with the FANCA protein, both in vivo and in… CONTINUE READING