A physical and functional map of the human TNF-α/NF-κB signal transduction pathway

@article{Bouwmeester2004APA,
  title={A physical and functional map of the human TNF-$\alpha$/NF-$\kappa$B signal transduction pathway},
  author={Tewis Bouwmeester and Angela Bauch and Heinz Ruffner and Pierre-Olivier Angrand and Giovanna Bergamini and Karen Croughton and Cristina Cruciat and Dirk Eberhard and Julien Gagneur and Sonja Ghidelli and Carsten Hopf and Bettina Huhse and Raffaella Mangano and Anne Marie Michon and Markus Schirle and Judith Schlegl and Markus Schwab and Martin Stein and Andreas Bauer and Georg Casari and Gerard Drewes and Anne-Claude Gavin and David B. Jackson and Gérard Joberty and Gitte Neubauer and Jens M. Rick and Bernhard Kuster and Giulio Superti-Furga},
  journal={Nature Cell Biology},
  year={2004},
  volume={6},
  pages={97-105}
}
Signal transduction pathways are modular composites of functionally interdependent sets of proteins that act in a coordinated fashion to transform environmental information into a phenotypic response. The pro-inflammatory cytokine tumour necrosis factor (TNF)-α triggers a signalling cascade, converging on the activation of the transcription factor NF-κB, which forms the basis for numerous physiological and pathological processes. Here we report the mapping of a protein interaction network… 
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