A physical and functional map of the human TNF-α/NF-κB signal transduction pathway

@article{Bouwmeester2004APA,
  title={A physical and functional map of the human TNF-α/NF-κB signal transduction pathway},
  author={T. Bouwmeester and A. Bauch and Heinz Ruffner and Pierre-Olivier Angrand and G. Bergamini and K. Croughton and Cristina Cruciat and Dirk Eberhard and J. Gagneur and S. Ghidelli and C. Hopf and B. Huhse and R. Mangano and A. Michon and M. Schirle and Judith Schlegl and M. Schwab and M. Stein and A. Bauer and G. Casari and G. Drewes and A. Gavin and D. B. Jackson and G. Joberty and G. Neubauer and Jens M. Rick and B. Kuster and G. Superti-Furga},
  journal={Nature Cell Biology},
  year={2004},
  volume={6},
  pages={97-105}
}
Signal transduction pathways are modular composites of functionally interdependent sets of proteins that act in a coordinated fashion to transform environmental information into a phenotypic response. The pro-inflammatory cytokine tumour necrosis factor (TNF)-α triggers a signalling cascade, converging on the activation of the transcription factor NF-κB, which forms the basis for numerous physiological and pathological processes. Here we report the mapping of a protein interaction network… Expand
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