A phylogenomic approach to reconstructing the diversification of serine proteases in fungi.

@article{Hu2004APA,
  title={A phylogenomic approach to reconstructing the diversification of serine proteases in fungi.},
  author={Gang Hu and Raymond J. St. Leger},
  journal={Journal of evolutionary biology},
  year={2004},
  volume={17 6},
  pages={
          1204-14
        }
}
Using a phylogenomic approach with 10 fungi of very different virulence and habitat, we determined that there was substantial diversification of subtilase-type proteases early in ascomycete history (with subsequent loss in many lineages) but with no comparable diversification of trypsins. Patterns of intron loss and the degree of divergence between paralogues demonstrated that the proliferation of proteinase K subtilases and subtilisin type subtilases seen in pathogenic ascomycetes (Metarhizium… CONTINUE READING
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