A phylogenetic analysis using full-length viral genomes of South American dengue serotype 3 in consecutive Venezuelan outbreaks reveals a novel NS5 mutation.

@article{Schmidt2011APA,
  title={A phylogenetic analysis using full-length viral genomes of South American dengue serotype 3 in consecutive Venezuelan outbreaks reveals a novel NS5 mutation.},
  author={Daniel J Schmidt and Brett E. Pickett and David Camacho and Guillermo Comach and Kris Xhaja and Niall J. Lennon and Katherine Rizzolo and N Blumenfeld De Bosch and Arturo Becerra and Maur{\'i}cio Lacerda Nogueira and Adriano Mondini and Edna Maria Vieira da Silva and Pedro F. C. Vasconcelos and Jorge Luis Mu{\~n}oz-Jord{\'a}n and Gilberto A. Santiago and Raquel Elvira Ocazionez and Lauren Gehrke and Elliot J. Lefkowitz and Bruce W. Birren and Matthew R. Henn and Immaculada Bosch},
  journal={Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases},
  year={2011},
  volume={11 8},
  pages={2011-9}
}
Dengue virus currently causes 50-100 million infections annually. Comprehensive knowledge about the evolution of Dengue in response to selection pressure is currently unavailable, but would greatly enhance vaccine design efforts. In the current study, we sequenced 187 new dengue virus serotype 3 (DENV-3) genotype III whole genomes isolated from Asia and the Americas. We analyzed them together with previously-sequenced isolates to gain a more detailed understanding of the evolutionary… CONTINUE READING