A phylogenetic analysis identifies heterogeneity among hepatocellular carcinomas.

@article{McGlynn2002APA,
  title={A phylogenetic analysis identifies heterogeneity among hepatocellular carcinomas.},
  author={Katherine A McGlynn and Michael Edmonson and Rita A Michielli and William T London and Wen yao Lin and Gong-Chao Chen and Fu-min Shen and Kenneth H. Buetow},
  journal={Hepatology},
  year={2002},
  volume={36 6},
  pages={1341-8}
}
Primary hepatocellular carcinoma (HCC) is a significant cause of cancer morbidity and mortality on the global scale. Although epidemiologic studies have identified major risk factors for HCC, the sequence of oncogenic events at the molecular level remains poorly understood. While genetic allele loss appears to be a common event, the significance of the loss is not clear. In order to determine whether allele loss appears to be a random event among HCCs or whether patterns of loss cluster in… CONTINUE READING