A phosphorylation site in the Na+ channel required for modulation by protein kinase C.

@article{West1991APS,
  title={A phosphorylation site in the Na+ channel required for modulation by protein kinase C.},
  author={J. W. West and Randal E Numann and B. J. Murphy and Todd Scheuer and William A. Catterall},
  journal={Science},
  year={1991},
  volume={254 5033},
  pages={866-8}
}
Voltage-gated sodium channels are responsible for generation of action potentials in excitable cells. Activation of protein kinase C slows inactivation of sodium channels and reduces peak sodium currents. Phosphorylation of a single residue, serine 1506, that is located in the conserved intracellular loop between domains III and IV and is involved in inactivation of the sodium channel, is required for both modulatory effects. Mutant sodium channels lacking this phosphorylation site have normal… CONTINUE READING