A phosphorylation-and-ubiquitylation circuitry driving ATR activation and homologous recombination

@inproceedings{Dubois2017APC,
  title={A phosphorylation-and-ubiquitylation circuitry driving ATR activation and homologous recombination},
  author={Jean-Christophe Dubois and Ma{\"i}lyn Yates and Antoine Gaudreau-Lapierre and Genevi{\`e}ve Cl{\'e}ment and Laurent Cappadocia and Luc Gaudreau and L. Q. Zou and Alexandre Mar{\'e}chal},
  booktitle={Nucleic acids research},
  year={2017}
}
RPA-coated single-stranded DNA (RPA-ssDNA), a nucleoprotein structure induced by DNA damage, promotes ATR activation and homologous recombination (HR). RPA is hyper-phosphorylated and ubiquitylated after DNA damage. The ubiquitylation of RPA by PRP19 and RFWD3 facilitates ATR activation and HR, but how it is stimulated by DNA damage is still unclear. Here, we show that RFWD3 binds RPA constitutively, whereas PRP19 recognizes RPA after DNA damage. The recruitment of PRP19 by RPA depends on PIKK… CONTINUE READING
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