A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria.

  title={A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria.},
  author={Christine L Gee and Kadamba Papavinasasundaram and Sloane R Blair and Christina E. Baer and Arnold M. Falick and David S. King and Jennifer E. Griffin and Harene Venghatakrishnan and Andrew Zukauskas and Jun-rong Wei and Rakesh K Dhiman and Dean C Crick and Eric J. Rubin and Christopher M. Sassetti and Tom Alber},
  journal={Science signaling},
  volume={5 208},
Prokaryotic cell wall biosynthesis is coordinated with cell growth and division, but the mechanisms regulating this dynamic process remain obscure. Here, we describe a phosphorylation-dependent regulatory complex that controls peptidoglycan (PG) biosynthesis in Mycobacterium tuberculosis. We found that PknB, a PG-responsive Ser-Thr protein kinase (STPK), initiates complex assembly by phosphorylating a kinase-like domain in the essential PG biosynthetic protein, MviN. This domain was… CONTINUE READING


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Structural insight into the Mycobacterium tuberculosis Rv 0020 c protein and its interaction with the PknB kinase

  • L. H. Pearl, A. W. Oliver
  • Structure
  • 2011

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