A phospholipid derivative of cytosine arabinoside and its conversion to phosphatidylinositol by animal tissue.

@article{Raetz1977APD,
  title={A phospholipid derivative of cytosine arabinoside and its conversion to phosphatidylinositol by animal tissue.},
  author={Christian R. H. Raetz and M Y Chu and Shekhar Srivastava and Joseph G. Turcotte},
  journal={Science},
  year={1977},
  volume={196 4287},
  pages={303-5}
}
We have synthesized an analog (ara-CDP-DL-dipalmitin) of cytidine diphosphate diglyceride (CDP-diglyceride) in which the antitumor drug, cytosine arabinoside, is substituted for the cytidine moiety. Enzymes in rat and human liver convert this analog to phosphatidylinositol, thereby releasing cytosine arabinoside-5'-monophosphate, an obligatory intermediate in the activation of cytosine arabinoside. Unlike cytidine diphosphate diglyceride, however, ara-CDP-DL-diapalmitin is not an efficient… CONTINUE READING
8 Citations
0 References
Similar Papers

Similar Papers

Loading similar papers…