A phospholipase A2 inhibitor (Ro 31-4493) prevents protein loss associated with the calcium paradox in isolated guinea pig hearts without effect on contracture, calcium overload, or the currents through L-type calcium channels.

@article{Suleiman1994APA,
  title={A phospholipase A2 inhibitor (Ro 31-4493) prevents protein loss associated with the calcium paradox in isolated guinea pig hearts without effect on contracture, calcium overload, or the currents through L-type calcium channels.},
  author={M-Saadeh Suleiman and Kenryo K. Minezaki and Kechen Ban and Robin A. Chapman},
  journal={Cardiovascular research},
  year={1994},
  volume={28 5},
  pages={650-5}
}
OBJECTIVE Although it is widely accepted that the hypercontraction provoked by the influx of Ca2+ on return to normal Tyrode solution after a period of Ca2+ depletion (the calcium paradox) contributes to the damage to the cell membrane, it remains possible that the Ca2+ overload activates intracellular enzymes that are important in the initial degradation of the cell membrane. This possibility was examined in this work. EXPERIMENTAL DESIGN The effect of Ro 31-4493, a phospholipase A2… CONTINUE READING

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