A phosphodiesterase III inhibitor protects rat liver from sinusoidal obstruction syndrome through heme oxygenase-1 induction.

@article{Narita2009API,
  title={A phosphodiesterase III inhibitor protects rat liver from sinusoidal obstruction syndrome through heme oxygenase-1 induction.},
  author={Masato Narita and Etsuro Hatano and Iwao Ikai and Aya Miyagawa-Hayashino and Atsuko Yanagida and Hiromitsu Nagata and Hiroyuki Asechi and Kojiro Taura and Shinji Uemoto},
  journal={Annals of surgery},
  year={2009},
  volume={249 5},
  pages={806-13}
}
OBJECTIVE The aim of study was to investigate pharmacological treatment for sinusoidal obstruction syndrome (SOS). BACKGROUND SOS is associated with oxaliplatin-based chemotherapy in patients with hepatic colorectal metastases. Patients with SOS have increased postoperative morbidity after major hepatectomy, but a method for effective prevention of SOS has not been established. METHODS Male Sprague-Dawley rats were treated with cobalt protoporphyrin IX (CoPP) or olprinone (OLP), a… CONTINUE READING
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