A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes.

@article{Varier2010APS,
  title={A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes.},
  author={Radhika A. Varier and Nikolay S. Outchkourov and Petra de Graaf and Frederik M. A. van Schaik and Henk Jan L Ensing and Fangwei Wang and Jonathan M. G. Higgins and Geert J. P. L. Kops and H. Th. Marc Timmers},
  journal={The EMBO journal},
  year={2010},
  volume={29 23},
  pages={3967-78}
}
Histone methylation patterns are correlated with eukaryotic gene transcription. High-affinity binding of the plant homeodomain (PHD) of TFIID subunit TAF3 to trimethylated lysine-4 of histone H3 (H3K4me3) is involved in promoter recruitment of this basal transcription factor. Here, we show that for transcription activation the PHD of TAF3 can be replaced by PHDs of other high-affinity H3K4me3 binders. Interestingly, H3K4me3 binding of TFIID and the TAF3-PHD is decreased by phosphorylation of… CONTINUE READING