A phenotypic screening approach in cord blood-derived mast cells to identify anti-inflammatory compounds.

@article{Kaur2013APS,
  title={A phenotypic screening approach in cord blood-derived mast cells to identify anti-inflammatory compounds.},
  author={Rejbinder Kaur and Lisa A. Sloan and Andy D. Blanchard and J. Lorrain Smith and Ian Churcher and Gareth J Wayne and Steven B. Ludbrook},
  journal={Journal of biomolecular screening},
  year={2013},
  volume={18 10},
  pages={
          1223-33
        }
}
Mast cells are unique hematopoietic cells that are richly distributed in the skin and mucosal surfaces of the respiratory and gastrointestinal tract. They play a key role in allergic inflammation by releasing a cocktail of granular constituents, including histamine, serine proteases, and various eicosanoids and cytokines. As such, a number of drugs target either inhibition of mast cell degranulation or the products of degranulation. To identify potential novel drugs and mechanisms in mast cell… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 29 REFERENCES

Basic science for the clinician 53: mast cells.

  • Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
  • 2011
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