A phenotypic comparison of osteoblast cell lines versus human primary osteoblasts for biomaterials testing.

@article{Czekanska2014APC,
  title={A phenotypic comparison of osteoblast cell lines versus human primary osteoblasts for biomaterials testing.},
  author={Ewa M Czekanska and Martin J Stoddart and James R. Ralphs and Robert Geoffrey Richards and J S Hayes},
  journal={Journal of biomedical materials research. Part A},
  year={2014},
  volume={102 8},
  pages={2636-43}
}
Immortalized cell lines are used more frequently in basic and applied biology research than primary bone-derived cells because of their ease of access and repeatability of results in experiments. It is clear that these cell models do not fully resemble the behavior of primary osteoblast cells. Although the differences will affect the results of biomaterials testing, they are not clearly defined. Here, we focused on comparing proliferation and maturation potential of three osteoblast cell lines… CONTINUE READING